Fun Path, Unit II - 1 Fundamentals of Pathology Exam 2...

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1 Fundamentals of Pathology Exam 2 Review Chapter 3: Repair: Cell Regeneration, Fibrosis, and Wound Healing Regeneration: Control of cell growth and differentiation at sites of injury largely controlled by local (micro) environment primary mechanism for stimulating growth is induction of resting cells into the growth cycle Cell cycle and proliferative potential cell cycle: G1   presynthetic  DNA synthesis G2   premitotic  mitotic G0   quiescent (resting) cells can be divided into 3 groups by way of their growth potential: continuously dividing cells [labile]  quiescent cells [stabile]  smooth muscle) nondividing cells [permanent]   mature cells – do not undergo mitosis (nerve cells, cardiac cells, skeletal muscle cells) Molecular events in cells growth growth factors work thru expression of genes   protooncogenes events in growth stimulation: ligand receptor binding   interaction between growth factor and membrane receptor or cytosolic/nuclear receptor receptor activation  signal transduction    activated receptors lead changes in molecules that activate second messenger systems – most activation due to activity of  kinases (mitogen activated protein kinases [MAPs]; phosphatases act as inhibitors by removing phosphate groups) transcription factors  (c-myc, c-fos) cell cycle and cyclins   control of cell cycle (entry from one phase to another) is dependent on the transcription of proteins called cyclins and  binding to another group of kinases called cyclin dependent kinases (cdk’s) – these complexes in turn phosphorylate many proteins required for  mitosis growth inhibition important in controlling tissue development examples of growth factors epidermal growth factor (EGF)  platelet-derived growth factor (PDGF) 
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This note was uploaded on 04/07/2008 for the course PATH 301 taught by Professor Taylor during the Spring '08 term at Palmer Chiropractic.

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Fun Path, Unit II - 1 Fundamentals of Pathology Exam 2...

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