Micro Final Exam Charts

Micro Final Exam Charts - 1 Microbiology Final Exam Study...

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1 Microbiology Final Exam Study Guide Spirochetes: (Chapter 41) Treponema spp., Borrelia spp, and Leptospira spp. TREPONEMA (2 species) Genus/Species T. pallidum pallidum T. pallidum endemicum T. carateum Characteristics cells thin, do NOT gram stain well, dark-field microscopy is used; stained with anti-treponemal antibodies labeled with fluroescent dyes; do NOT survive off the body; die quickly if exposed to low temps or dry Where Found humans only – not found in animals; infection by person-to-person contact (sex) , blood transfusion, cogenital transmission Condition syphilis endemic syphilis pinta Virulence Factors Clinical Syndromes Syphilis – 3 stages (see chart below for stages) Diagnoses treponeme in chancre or rash & ID with dark-field or immunofluorescence; antibody tests; Wassermann (old test) -–not used anymore due to false positives Tests nonspecific treponemal antibody tests; pt’s serum is mixed with reagin type antigen; beef cardiolipin is used Nonspecific Test VDRL = Veneral Disease Research Laboratory test: pt’s serum placed on slide with reagin; flocculation (gummy, sticky substance) indicates positive reaction Nonspecific Test RPR = Rapid Plasma Reagin test: white plastic coated card, tiny carbon particles with reagin antigen Specific Test TPI = Treponemal pallidum Immobilization test: treponeme (from lab rabbit) and pt’s serum mixed – dark-field microscopy used to see if treponeme is immobiilized Specific Test FTA-ABS = Fluorescent treponemal antibody absorption test: indirect immunofluorescence test; Ab from patient + Ag + antihuman gamma globulin + fluorescent dye examined microscopically; treponemes will fluoresce if present Specific Test MHA-TP = micro-hemagglutination test for T. pallidum reagin = lipid-like substance the body makes in response to various infections specific tests use antigens antibiotics can be used to treat this, but it is difficult to find in subsequent exposures T. pallidum pertenue non-veneral disease (transmitted by flies) Yaws or frambesia (red raspberry lesions) some cross immunity to syphilis infection by contact vectors flies disease of impoverished children in warm, tropical countries clinical syndrome: mother yaw forms at site of entry of treponeme into the body secondary lesions appear months later – these ulcerate & heal
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2 Syphilis Stages: Primary Syphilis chancre at site of initial contact – painless, circular, purplish with firm, raised margin ; treponeme alive in lesion; adenopathy seen 1-2 weeks after chancre; chancre disappears 2-6
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This note was uploaded on 04/07/2008 for the course MICRO 101 taught by Professor Micro during the Spring '08 term at Palmer Chiropractic.

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Micro Final Exam Charts - 1 Microbiology Final Exam Study...

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