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Unformatted text preview: 1 Endocrinology Exam I Objectives SPINAL MANIPULATON AND BETA-ENDORPHIN 1. Dr. Howard Vernon article objectives: Explain the intent of the study: to demonstrate the effect of spinal manipulation on plasma beta-endorphin levels List the method used to assess the plasma beta-endorphin levels: assessed by radioimmune assay technique samples were taken by venipuncture at -20, -5, +5, +10, and +30 minutes Explain the results of the experimental group at the 5-minute post intervention point: there was an increase in serum beta-endorphin levels Explain the hypothesis made by Dr. Howard Vernon regarding the pain relieving affect of manipulation: the pain-relieving effect of manipulation is due to a short-term increase in beta-endorphin levels Explain the hypothesis of manipulation effecting proprioceptive transmission: manipulation produces significant short-term bursts of proprioceptive transmission in the large caliber myelinated alpha-afferent fibers from the spinal joint capsules and ligaments and in the muscle spindles of the local paraspinal musculature Explain the effectiveness of manipulation on the segmental motor pool. sensor motor reflex connections are influenced by manipulation via stimulation of the segmental motor pools Explain how manipulation neurologically would result in a reduction of the brain transmission and of muscle hypertonicity: reduction of brain transmission is via inhibition of the ascending pain pathways reduction of muscle hypertonicity is via inhibition of alpha motor neurons Explain the mechanism for the effect of the TENS and spinal manipulation on pain. TENS: gating effect of nociceptive afferent stimulation and the release of endorphins Identify the results of electro acupuncture on beta-endorphins. caused elevations of beta-endorphins in the plasma of healthy volunteers Identify areas that should be further investigated as indicated by Dr. Vernon. this same area of study with larger samples, more control, etc. neuroanatomical pathway studies in animal models Explain the conceptual model of the neurohormonal effects of spinal manipulation on enkephalin and endorphins: manipulation can increase paraspinal cutaneous pain tolerance levels, thus leading to the possibility of the release of a neurotransmitter capable of modulating pain transmission as a result of spinal manipulation Explain the 2 theories as to how the adjustment affected pain: impulse based: phenomena related to reflex behaviors of the spinal neuromere and the CNS as they are sustained and disturbed by motion segment dysfunction non-impulse based: phenomena related to the physical or structural status of nerves and to the behavior of materials internal to nerve...
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- Spring '08