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Unformatted text preview: 1 Endocrinology Exam I Objectives “SPINAL MANIPULATON AND BETA-ENDORPHIN” 1. Dr. Howard Vernon article objectives: Ÿ Explain the intent of the study: Ÿ to demonstrate the effect of spinal manipulation on plasma beta-endorphin levels Ÿ List the method used to assess the plasma beta-endorphin levels: Ÿ assessed by radioimmune assay technique Ÿ samples were taken by venipuncture at -20, -5, +5, +10, and +30 minutes Ÿ Explain the results of the experimental group at the 5-minute post intervention point: Ÿ there was an increase in serum beta-endorphin levels Ÿ Explain the hypothesis made by Dr. Howard Vernon regarding the pain relieving affect of manipulation: Ÿ the pain-relieving effect of manipulation is due to a short-term increase in beta-endorphin levels Ÿ Explain the hypothesis of manipulation effecting proprioceptive transmission: Ÿ manipulation produces significant short-term bursts of proprioceptive transmission in the large caliber myelinated alpha-afferent fibers from the spinal joint capsules and ligaments and in the muscle spindles of the local paraspinal musculature Ÿ Explain the effectiveness of manipulation on the segmental motor pool. Ÿ sensor motor reflex connections are influenced by manipulation via stimulation of the segmental motor pools Ÿ Explain how manipulation neurologically would result in a reduction of the brain transmission and of muscle hypertonicity: Ÿ reduction of brain transmission is via inhibition of the ascending pain pathways Ÿ reduction of muscle hypertonicity is via inhibition of alpha motor neurons Ÿ Explain the mechanism for the effect of the TENS and spinal manipulation on pain. Ÿ TENS: gating effect of nociceptive afferent stimulation and the release of endorphins Ÿ Identify the results of electro acupuncture on beta-endorphins. Ÿ caused elevations of beta-endorphins in the plasma of healthy volunteers Ÿ Identify areas that should be further investigated as indicated by Dr. Vernon. Ÿ this same area of study with larger samples, more control, etc. Ÿ neuroanatomical pathway studies in animal models Ÿ Explain the conceptual model of the neurohormonal effects of spinal manipulation on enkephalin and endorphins: Ÿ manipulation can increase paraspinal cutaneous pain tolerance levels, thus leading to the possibility of the release of a neurotransmitter capable of modulating pain transmission as a result of spinal manipulation Ÿ Explain the 2 theories as to how the adjustment affected pain: Ÿ impulse based: phenomena related to reflex behaviors of the spinal neuromere and the CNS as they are sustained and disturbed by motion segment dysfunction Ÿ non-impulse based: phenomena related to the physical or structural status of nerves and to the behavior of materials internal to nerve...
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- Spring '08
- Endocrine System, Anterior pituitary, Gigantism