Chapter 21 The Immune System BB Version

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Unformatted text preview: Antigenic determinants Antigen Antibody B Antibody C Figure 21.7 MHC: major histocompatability complex complex Cell external surfaces have protein molecules, Cell termed self antigens termed Glycoproteins mark cells as self Each MHC is different for each individual Class I: found on all cells Class II: only certain cells acting in immune Class response response Cells of the immune system Cells Three cell types Lymphocytes T – cells: non-antibody-producing, cell cells: mediated immunity mediated B – cells: humoral immunity Antigen-presenting cells (APC): no Antigen-presenting specific antigens, but play an auxiliary role specific Lymphocytes Lymphocytes Maturation depends on the cell becoming Maturation immunocompetent: able to recognize and bind immunocompetent able to an antigen to T-cells: 2-3 day process to mature (under T-cells: thymus hormones) to identify foreign antigens thymus Positive selection: recognize own tissues when bound Positive to an antigen to Negative selection: bind to self-proteins Must become self-tolerant, unresponsive to selfantigens T cell selection in the thymus T cell selection in the thymus Lymphocytes Lymphocytes B-cells: in bone marrow, but little is known B-cells: about the factors controlling maturation about Immunocompetence in organs that Immunocompetence activate lymphocytes termed primary lymphoid organs. All other lymphoid organs are secondary lymphoid organs. organs Adaptive defenses Immature lymphocytes Red bone marrow: site of ly...
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