Unformatted text preview: Complement Complement and Neutralization
Complement Compliment Against cells (bacteria, etc), binding causes a
3D change and exposed complement binding
sites, leading to cell lysis
sites, Neutralization Block specific sites on the antigen (i.e.
exotoxins), minimizing the toxic effect of the
antibody. Toxins are unable to be released.
Eventually, antibody is phagocytized
Eventually, Agglutination and Precipitation
Agglutination Agglutination Cross-linking of antigen-antibody complexes,
causing clumping. IgM especially effective
causing Precipitation Soluble molecules (not cells) are cross-linked
into complexes and settle out of solution. Eventually, both types phagocytized Mechanisms of antibody action
Adaptive defenses Humoral immunity
complex Antibody Inactivates by
parts of bacterial
exotoxins; viruses) Agglutination
(cell-bound antigens) Enhances
Phagocytosis Fixes and activates
(soluble antigens) Enhances Complement Leads to
Inflammation Cell lysis Chemotaxis Histamine
release Figure 21.15 Antibodies have a PLAN
Antibodies P = precipitation L = lysis (by complement) A = agglutination N = neutralization Cell mediated immune response
Cell What about diseases that are infectious, that
stay inside cells?
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This note was uploaded on 04/11/2013 for the course BIOL 361 taught by Professor Unkown during the Spring '12 term at University of Texas.
- Spring '12