Chapter 21 The Immune System BB Version

How act against antigens virus bacteria toxins act

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Unformatted text preview: Complement Complement and Neutralization Complement Compliment Against cells (bacteria, etc), binding causes a Against 3D change and exposed complement binding sites, leading to cell lysis sites, Neutralization Block specific sites on the antigen (i.e. Block exotoxins), minimizing the toxic effect of the antibody. Toxins are unable to be released. Eventually, antibody is phagocytized Eventually, Agglutination and Precipitation Agglutination Agglutination Cross-linking of antigen-antibody complexes, Cross-linking causing clumping. IgM especially effective causing Precipitation Soluble molecules (not cells) are cross-linked Soluble into complexes and settle out of solution. Eventually, both types phagocytized Mechanisms of antibody action Adaptive defenses Humoral immunity Antigen Antigen-antibody complex Antibody Inactivates by Neutralization (masks dangerous parts of bacterial exotoxins; viruses) Agglutination (cell-bound antigens) Enhances Phagocytosis Fixes and activates Precipitation (soluble antigens) Enhances Complement Leads to Inflammation Cell lysis Chemotaxis Histamine release Figure 21.15 Antibodies have a PLAN Antibodies P = precipitation L = lysis (by complement) A = agglutination N = neutralization Cell mediated immune response Cell What about diseases that are infectious, that What stay inside cells? st...
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This note was uploaded on 04/11/2013 for the course BIOL 361 taught by Professor Unkown during the Spring '12 term at University of Texas.

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