Chapter 21 The Immune System BB Version

Synthesized in recognized the er and passed to plasma

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Unformatted text preview: roteins) that are repackaged (Golgi) and displayed and So what’’s so important about these s So MHC proteins? MHC They provide the clue that an infectious They microorganism resides within a cell microorganism MHC proteins, and antigen processing and display: Class I protein MHC proteins, and antigen processing and display: MHC proteins, and antigen processing and display: Class II protein MHC proteins, and antigen processing and display: T-cell activation T-cell Two step process Antigen binding T-cell antigen receptors bind to an antigen-MHC T-cell complex complex Termed naïve T-cells at this stage (activated) Costimulation Must recognize costimulatory signals (safeguard) Activated T-cell enlarges and proliferates forming a Activated clone clone Perform functions according to the T-cell class The role of Helper T-cells The Chemically or directly stimulate the Chemically proliferation of other T-cells and B-cells bound to antigens bound Essentially, they recruit other immune Essentially, cells to create the immune response cells Stimulate T-cell proliferation and antibody Stimulate production in B-cells production Cytotoxic & helper T cells Cytotoxic & helper T cells The central role of helper T cells Cytotoxic T-cells Cytotoxic Killer T-cells directly attack and kill cells Circulate in body, bind to target cells Circulate (wrong MHC I), and activates a lethal hit: lethal Bind and release perforin into the plamsa Bind perforin membrane membrane Detaches and co...
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