Chapter 21 The Immune System BB Version

G rheumatic fever react rheumatic hypersensitivities

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Unformatted text preview: in 1 - 3 hours, lasts for 10 - 15 hours Begin Delayed Begin in 1 - 3 days Immediate allergy Immediate Anaphylaxis First exposure sensitizes the person, without First symptoms symptoms Produce huge amounts of antibody (IgE), and attach to Produce mast cells and basophils mast Second encounter: flood of histamine and Second inflammatory chemicals (e.g. chemotactic and prostaglandins) prostaglandins) Atopy Spontaneous allergy without previous exposure (10%) Anaphylaxis Anaphylaxis May be local or systemic Local Runny nose, hives, watery eyes, etc. Runny Antihistamine OTC (over the counter) medicine used to counteract effects medicine Systemic Anaphylactic shock- basophils and mast cells Anaphylactic recruited throughout the body recruited Constrict bronchioles, possible circulatory collapse Mechanism of an acute allergic response Mechanism of an acute allergic response Subacute allergy Subacute Remember 1-3 hours Caused by antibodies (IgG, IgM, not IgE as Caused not IgE before) before) Cytotoxic: Binding of antibodies stimulate phagocytosis (e.g. Mismatched blood transfusions) transfusions) Immune complex: cannot clear the antibody- antigen complex from an area. Intense antigen inflammation occurs, severely damaging tissues And Finally, Delayed hypersensitivity And Basically, a cell-mediated hypersensitivity Basically, including both cytotoxic and hypersensitive Tincluding cells Depends on cytokine activated macrophages Depends and non-specific killing and Contact dermatitis (e.g. Poison ivy or poison Contact oak, cosmetics, heavy metals) oak, Has protective functions: Against pathogens, resistance to cancer, rejection to Against foreign grafts or transplanted organs foreign The End...
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