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Unformatted text preview: oducing
autoanitbodies Termed an autoimmunity, or an
autoimmune Types of Autoimmune diseases
Types Multiple sclerosis: white matter of brain and spinal cord
Myasthenia gravis: impairs neuromuscular
Grave’s disease: excess thyroxine
Type I (juvenile) diabetes mellitus: β cells,
losing insulin and the use of carbohydrates
Systemic lupus erythematosus (SLE): kidney,
heart, lungs, skin
Glomerulonephritis: renal function
Rheumatoid arthritis (RA): joints How can you lose detection of self?
How Lymphocyte programming ineffective T and B cells during programming phase in
thymus and bone marrow escape rather than
be destroyed (occurs in multiple sclerosis)
multiple New self-antigens appear By gene mutation or hapten attachment as a
result of infectious damage
result Foreign antigens resemble self-antigens Similar determinants of foreign and self crossreact (e.g. rheumatic fever)
rheumatic Hypersensitivities (i.e. allergies)
Hypersensitivities Fighting a perceived threat: allergen Three different types of hypersensitivities Immediate Begin in seconds, lasts for about ½ an hour Subacute Begin...
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This note was uploaded on 04/11/2013 for the course BIOL 361 taught by Professor Unkown during the Spring '12 term at University of Texas at Austin.
- Spring '12