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11 vegf bfgf basic fibroblast factor tgf b

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Unformatted text preview: ngiogenesis and Metastasis 9. Proliferation/Migration endothelial cells Proliferation/Migration triggered by “angiogenic growth factors” triggered – – – – 10. 11. VEGF bFGF (basic fibroblast factor) TGF-b (transforming growth factor-b) PDGF (platelet-derived growth factor) Blood vessels in tumor allow tumor cells to Blood enter the bloodstream enter Migration to distant tissues (metastases) Angiogenesis and Metastasis Angiogenesis Cancer Treatment Cancer Chemotherapy Radiation Surgery Hormonal therapy Immunotherapy – – – – Immunomodulating agents Interferon Antigens Monoclonal antibodies Cancer Treatment Cancer Chemotherapy – Directed at destroying tumor cells » Cells actively dividing » That are still capable of entering the cell cycle and dividing That (G0 to G1 phase) (G – Small tumors - faster growing » More sensitive to chemotherapy – Large tumors - slower growing » Mildly sensitive to chemotherapy Cancer Treatment Cancer Example – Second generation chemotherapeutic agent » Taxotere Disrupts cellular microtubules Microtubules are important in cell division Rapidly dividing cells are sensitive to these Rapidly agents (cancer cells) agents Cancer Treatment Cancer Chemotherapy (continued) – “multidrug resistance protein” (MDR) » Tumors expressing a cell membrane surface glycoprotein termed “P170” Protein functions as a transporter moving chemotherapy drugs out of the Protein cell cell Radiation therapy – Rapidly dividing cell...
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