Cancer16BB

Clumps of cells off the primary tumor have a clumps

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Unformatted text preview: Metastasis by lymphatics and bloodstream Metastasis (continued) (continued) 5. Clumps of cells (off the primary tumor) have a Clumps better chance of survival better 6. Most common metastatic route is the lymph » » Lymphatic channels at margins of the tumor Cells carried to lymphatic nodes Tumor Spread Tumor Mechanisms of Metastasis Metastasis by blood stream 1. – Cell penetrate blood vessels Within the blood stream tumor cells must » » » – Survive immune attack Survive mechanical stress of blood flow Attach and break through the vessel walls Tumors can shed cells as they grow » Millions of cell can be released Tumor Spread Tumor Angiogenesis and Angiogenesis Factors Angiogenesis Tumor growth dependent on getting blood supply – – “angiogenesis” new blood vessels development Without blood supply tumor cells die » Blood - oxygen, nutrients and removes waste Tumor Spread Tumor Angiogenesis and Angiogenesis Factors Angiogenesis Pro-angiogenic factors identified – – – – Endothelial growth factor (VEGF) Platelet-derived growth factor (PDGF) Transforming growth factor (TGF) Fibroblast growth factor (FGF) Tumor Spread Tumor Angiogenesis and Angiogenesis Factors Angiogenesis Inhibitors of angiogenesis – – – – Platelet factor- 4 Angiostatin Endostatin Vasostatin Tumor factor identified in angiogenesis – “tissue factor” (TF) Tumor Spread Tumor Angiogenesis and Angiogenesis Factors Angiogenesis Normal cells block angiogenesis using...
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