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Decreased cell cell adhesion 4 increased motility of

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Unformatted text preview: eased cell-cell adhesion 4. Increased motility of tumor cells 5. Release of lytic enzymes Factors probably independent Any combination of these factors can lead to Any local spread local Tumor Spread Tumor Local Invasion Cellular Multiplication – Invasion depends on cellular multiplication rate » Number of cells dividing Tumor Spread Tumor Local Invasion Mechanical Invasion – – Mechanical pressure from tumor growth Pressure disrupts circulation to local normal tissue Pressure leading to tissue death leading – Enhances tumor spread Tumor Spread Tumor Local Invasion Decreased Cell-Cell adhesion – Tumor cells do not adhere to each other or normal Tumor cells cells – Thus cells more likely to spread or break off from the Thus initial mass initial – Possible mechanisms » Fibronectin - important in cell attachment Cancer cells may produce abnormal fibronectin Or cancer cells may breakdown fibronectin during growth Tumor Spread Tumor Local Invasion Increased motility 1. 2. Tumor cells infiltrate adjacent tissues Pass through the vascular walls - enter circulation Pass “intravasati...
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