Unformatted text preview: tumor cells
» Attach to vessel walls that cross the basement membrane Tumor Spread
Theory of Tumor Invasion Invasive Tumors
Poorly Organized Tissues Cytokines and Chemokines Affect
Tumor Theory - Carcinogenesis of Skin Cancer
Theory New Horizons in Cancer Research
RNAi RNAi blocks cancer specific genes (eg. Protein
degrading How does RNAi work?
– siRNA a type of double stranded RNA
» Termed “small interfering RNA” – Consists of…..
» “sense” and “anti-sense” RNA sequences to a specific gene
» Complexes with proteins such as endoribonucleases Can cleave double stranded RNA New Horizons in Cancer Research
Sense and Anti - sense sequences Target gene sequence (mRNA) (cancer gene) GCGGAA Sense (mRNA) (target) CGCCUU Anti - sense (mRNA) New Horizons in Cancer Research
1. Small pieces of double stranded RNA termed
“siRNA” enters the tumor cell
– 1. siRNA (= small interfering RNA) In the cell it forms “RNA-induced silencing
– Consists of siRNA and
Protein = endonuclease...
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- Spring '11
- Physiology, tumor cells, primary tumor