Cancer16BB

Invasion protease inhibitors suggested in treatment

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Unformatted text preview: rades extracellular matrix during tumor cell invasion – Protease inhibitors suggested in treatment Protease Tumor Spread Tumor Theory of Tumor Invasion Three-step theory of tumor invasion – Events occur after tumor cells detach – Three major steps - sequences of events 1. Tumor cell attachment to the matrix Extracellular matrix 1. Degradation of the matrix 2. Locomotion into the matrix Tumor Spread Tumor Theory of Tumor Invasion Tumor cells attach to the matrix – Tissues separated by 2 types of extracellular matrix Basement membrane Interstitial connective tissue » Consist of collagens, proteoglycans and glycoproteins Glycoproteins = laminin and fibronectin Tumor Spread Tumor Theory of Tumor Invasion Tumor cells have receptors for laminin – Allow attachment to the matrix Evidence for the role of laminin – Direct correlation between tumor invasiveness and Direct amount of laminin receptors on tumor cells amount Tumor Spread Tumor Theory of Tumor Invasion Function of laminin and receptors – Laminin receptor and laminin form a bridge (tumor Laminin cell to matrix) cell Next step - attached tumor cell secretes Next proteolytic enzymes proteolytic – (or stimulates other cells to secrete enzymes) Tumor Spread Tumor Theory of Tumor Invasion Secretion of proteolytic enzymes – – Degrades matrix layer Proteases overwhelm protease inhibitors Third step - tumor moves into the degraded Third regions of the matrix regions – Projections (pseudopodia) extend from the...
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