Cancer16BB

Proceed tumor spread tumor angiogenesis and

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Unformatted text preview: “Thrombospondin” Theory that cancer cells stop producing Theory thrombospondin thrombospondin – Allows angiogenesis to proceed Tumor Spread Tumor Angiogenesis and Angiogenesis Factors Angiogenesis Molecular Events Leading to Tumor Growth and Metastasis Tumor Molecular Level Molecular Angiogenesis and Metastasis 1. Hypoxic Effects – 1. 2. Hypoxic-inducible factor -1a (HIF-1a) increases HIF-1a enters nucleus and dimerizes with HIF-1a ARNT ARNT – 1. Tumor cells furthest from blood supply - hypoxic ARNT (aryl hydrocarbon receptor nuclear ARNT translocator) translocator) Activates multiple genes including VEGF – = “Vascular endothelial growth factor” Molecular Level Molecular Angiogenesis and Metastasis 5. VEGF - the angiogenic “switch” – 6. 7. 8. Formation of new blood vessels Tumor growth supported by new blood vessels Tumor cells/endothelial cells increase Tumor metalloproteinases (MMPs) metalloproteinases Degrades extracellular matrix + causes Degrades “budding” “budding” – New blood vessels “bud” from existing vessels Molecular Level Molecular A...
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