To cytotoxic agents antigens ricin immunotoxin or

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Unformatted text preview: sotopes Monoclonal visualize tumor sites visualize Primary and secondary tumor sites Cancer Treatment Cancer Immunotherapy Monoclonal antibodies – Treatment » Monoclonal antibodies against tumor cell surface Monoclonal antigens conjugated to cytotoxic agents antigens Ricin (immunotoxin) or porphyrins Ricin (phototoxins) (phototoxins) » Monoclonal antibody conjugated with cytoxic Monoclonal agent binds to tumor cell agent » Cytotoxic agent kills cancer cell Cancer Treatment Cancer Immunotherapy Monoclonal antibodies – Example - “herceptin” » Monoclonal antibody against the HER2 receptor » Growth hormone receptor Unknown which growth factor binds to it » Commonly used to treat some forms of breast Commonly cancer cancer Cancer Treatment Cancer Immunotherapy Mechanism - herceptin (continued) Mechanism herceptin – Tumors (breast cancer) the HER2 gene becomes Tumors amplified (many copies) amplified » Termed “overexpression” – Results in high amounts of mRNA for HER2 protein – Produces high amounts of the HER2 receptor Cancer Treatment Cancer Immunotherapy Mechanism - herceptin (continued) Mechanism herceptin – Overexpression of the HER2 receptor on the cell Overexpression surface surface » Results in “homodimer” complexes of the HER2 receptor » Activates the receptors (w/o growth hormone) Constitutively active (active all the time) » Activates cell division and growth Cancer Treatment Cancer Immunotherapy Mechanism - herceptin (contin...
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