Cancer14BB

Carcinogenesis viral carcinogenesis theory oncogenic

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Unformatted text preview: s possesses oncogenes – Termed “v - onc” “c - onc” - oncogenes in normal cells onc” (nontransformed cells) (nontransformed – Collectively termed proto-oncogenes – Likely to be important in normal cellular function Oncogenic Viruses Oncogenic Mechanisms of Viral Carcinogenesis Viral carcinogenesis theory – – Oncogenic viral infections can lead to the Oncogenic transformation of normal cells to neoplastic cells transformation Two mechanisms 1. Direct mechanism - “insertional mutagenesis” Oncogenic Viruses Oncogenic Mechanisms of Viral Carcinogenesis Two mechanisms - continued… 2. Indirect mechanisms » » Viral infection damages tissue Cellular repair mechanisms accelerate cell proliferation Cellular localized region localized Actively dividing cells are at higher risk of mutation than other Actively cells cells Higher risk of transformation by mutation and transformation by Higher other carcinogens other Oncogenic Viruses Oncogenic Mechanisms of Viral Carcinogenesis 2. Indirect mechanisms - (continued) – Alternative - viral infection suppresses immune Alternative system system » Allows transformed cells to proliferate that would Allows normally be removed by the immune system normally...
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