Antibodies cytokines coordinate these responses

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Unformatted text preview: m recognize Helper foreign antigens foreign Secretes cytokines - activate T and B cells – T - cells mediate cellular inflammatory response – B - cells produce antibodies Cytokines coordinate these responses Acquired Immunodeficiency Syndrome (AIDS) Syndrome Acquired Immunodeficiency Syndrome (AIDS) Syndrome Acquired Immunodeficiency Syndrome (AIDS) Syndrome AIDS Treatment AIDS HAART AIDS Treatment AIDS Why is it so difficult to treat (or cure)? Virus incorporates into the genetic material of the host the Vaccines 1. HIV is genetically and antigenically highly variable HIV (similar to influenza virus) (similar » 30 to 40 different variants during the progression of the 30 disease disease AIDS Treatment AIDS 2. Vaccines (continued) AIDS patients have antibodies against HIV but AIDS no protection occurs no – Vaccines induce antibodies which may not be Vaccines effective effective 3. HIV spreads from cell to cell (hidden from HIV antibodies) antibodies) Vaccine Failure Vaccine Setback for AIDs Fight (Mar 2008) Vaccine Failure Vaccine Setback for AIDs Fight (Mar 2008) Greater risk in people with previous antibodies to Greater adenovirus adenovirus – Before the vaccination Before Adenovirus infection caused activation of immune Adenovirus system system – Caused proliferation of CD4 cells (have CCR5) Caused – Remember- major target of HIV Remember- Provided a bigger target for HIV Provided Patients more readily infected Patients FDA Approves “Combo” AIDS Drugs Drugs Currently AIDS patients take multiple medications at Currently multiple times multiple Pharmaceutical companies recently have collaborated Pharmaceutical to combine multiple meds into one tablet to – Combines mutliple AIDS drugs into a single once a day Combines tablet tablet Advantages – – Cheaper AIDS drug Better patient compliance Single Patient Cured Single Patient with HIV and Leukemia – – Potential Treatment - 2009 Potential Zinc Finger Technology New way to insert/delete/inactive genes “Zinc Finger “ proteins Zinc – – New Application – Editing cells DNA – Inserting genes at a specific site » Virus gene treatment not site specific Zinc Finger Potential Treatment Zinc Dr. Carl June (U. Penn) AIDS patient T - Helper cells collected IN THE LABORATORY Zinc fingers used to disable CCR5 gene in T Zinc Helper cells Helper 1. 2. – – 3. 3. 4. 4....
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