{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Alt.Immunity3BB

Causes increased gastric smooth secretion secretion

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: le of gut - causes increased gastric Smooth secretion secretion – Mast cells have H1/H2 receptors » Decreases release of histamine from mast cells » Negative feedback loop Mechanisms of Hypersensitivity Mechanisms IgE - Mast Cell General Mechanism Mechanisms of Hypersensitivity Mechanisms IgE - Mast Degranulation Mechanisms of Hypersensitivity Mechanisms Further Role of Histamine Chemotatic factor for eosinophils 1. Enhances eosinophils attraction to the inflammatory Enhances reaction reaction 2. Deactivates eosinophils to prevent them from Deactivates leaving the inflammatory site leaving Mechanisms of Hypersensitivity Mechanisms Role of the Autonomic NS Mechanisms of Hypersensitivity Mechanisms Type I Reactions (IgE) Clinical Aspects Histamines mediated responses Target tissues with large numbers of mast cells – GI tract - vomiting, diarrhea, gut pain » Foods - nuts, milk, chocolate, citrus, eggs Potential mediators – Foods- nuts, milk, eggs Mechanisms of Hypersensitivity Mechanisms Type I Reactions (IgE) Clinical Aspects Histamines mediated responses Target tissues with large numbers of mast cells – Skin - urticaria (hives) - white filled areas surrounded by redness redness » Nonimmunologic urticaria - emotional stress, cold temperature Nonimmunologic exposure (caused by the autonomic NS) exposure – Respiratory tract - bronchospasms, edema » Wheezing and labored breathing Wheezing Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Definition – Target cell destruction by antibodies against antigens on the cell’s plasma membrane surface » Surface antigens are termed “tissue-specific antigens” Surface “tissue-specific – Only cells or tissues with tissue-specific antigens are Only susceptible susceptible Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) - Graves Disease Dermatopathy – Thickening of the skin Exophthalmos – Protruding eyes Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Targets of Hypersensitivity Targets Allergy Targets of Hypersensitivity Targets Allergy Drug allergies - example penicillin – – – – Usually a penicillin metabolite Binds to RBC plasma membrane Induces antibody...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern