Alt.Immunity3BB

Alt.Immunity3BB

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: le of gut - causes increased gastric Smooth secretion secretion – Mast cells have H1/H2 receptors » Decreases release of histamine from mast cells » Negative feedback loop Mechanisms of Hypersensitivity Mechanisms IgE - Mast Cell General Mechanism Mechanisms of Hypersensitivity Mechanisms IgE - Mast Degranulation Mechanisms of Hypersensitivity Mechanisms Further Role of Histamine Chemotatic factor for eosinophils 1. Enhances eosinophils attraction to the inflammatory Enhances reaction reaction 2. Deactivates eosinophils to prevent them from Deactivates leaving the inflammatory site leaving Mechanisms of Hypersensitivity Mechanisms Role of the Autonomic NS Mechanisms of Hypersensitivity Mechanisms Type I Reactions (IgE) Clinical Aspects Histamines mediated responses Target tissues with large numbers of mast cells – GI tract - vomiting, diarrhea, gut pain » Foods - nuts, milk, chocolate, citrus, eggs Potential mediators – Foods- nuts, milk, eggs Mechanisms of Hypersensitivity Mechanisms Type I Reactions (IgE) Clinical Aspects Histamines mediated responses Target tissues with large numbers of mast cells – Skin - urticaria (hives) - white filled areas surrounded by redness redness » Nonimmunologic urticaria - emotional stress, cold temperature Nonimmunologic exposure (caused by the autonomic NS) exposure – Respiratory tract - bronchospasms, edema » Wheezing and labored breathing Wheezing Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Definition – Target cell destruction by antibodies against antigens on the cell’s plasma membrane surface » Surface antigens are termed “tissue-specific antigens” Surface “tissue-specific – Only cells or tissues with tissue-specific antigens are Only susceptible susceptible Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) - Graves Disease Dermatopathy – Thickening of the skin Exophthalmos – Protruding eyes Mechanisms of Hypersensitivity Mechanisms Tissue-Specific Reactions (type II) Targets of Hypersensitivity Targets Allergy Targets of Hypersensitivity Targets Allergy Drug allergies - example penicillin – – – – Usually a penicillin metabolite Binds to RBC plasma membrane Induces antibody...
View Full Document

This note was uploaded on 04/18/2013 for the course BIO 205 taught by Professor Dr.cady during the Spring '11 term at Bradley.

Ask a homework question - tutors are online