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Alt.Immunity3BB

Pericarditis renal disorder proteinitis neurological

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Unformatted text preview: cers Arthritis of at least 2 Arthritis peripheral joints peripheral Pleurisy, pericarditis Renal disorder – Proteinitis Neurological disorder – Seizures or psychosis Hemolytic anemia Immunologic disorders – Autoantibodies (eg. DNA) Antinuclear antibody Autoimmunity - Clinical Example Autoimmunity Systemic Lupus Erythematosis Treatments Anti-inflammatory agents – – – – Prednisone Asprin Ibuprofen COX2 inhibitor Immunosuppressive agents – Cyclosporine - reduces organ damage Stress management Autoimmunity - Clinical Example Autoimmunity Systemic Lupus Erythematosis Autologous stem cell transplants 1. 2. 3. 4. Patients bone marrow stem cells harvested CD34 stem cells isolated (early stem cells) High dose chemotherapy - destroys bone marrow Isolated stem cells transplanted back into the patient Concept - immune system is re-started Targets of Hypersensitivity Alloimmunity Alloimmunity Targets of Hypersensitivity Alloimmunity Alloimmunity Some examples of “transient neonatal diseases” – Graves disease » Maternal antibody against TSH receptor on neonatal thyroidexcessive release of thyroid hormone excessive – Myasthenia gravis » Maternal antibodies bind to acetylcholine receptor at neuromuscular junction in neonate junction Acetylcholine a neurotransmitter at the muscle » Causes muscle weakness Acquired Immunodeficiency Syndrome Acquired (AIDS) Acquired Immunodeficiency Syndrome (AIDS) Syndrome Epidemiology (2007 data) – Currently 1 million living with AIDS (US) – Since start of AIDS epidemic 1.5 million infected » 524,000 died from AIDS – 40,000 infected each year (50% 25 yrs or younger) » 48% African-American – – – Last 20 years number of women infected tripled 90% of most severe case die within 5 years if untreated 90% if New treatments have influenced the disease » 47% decline in deaths 1996 to 1997 Acquired Immunodeficiency Syndrome (AIDS) Syndrome Epidemiology (continued) 2007 -- Worldwide -– 33.4 million live with AIDS » » – 5700 die from AIDS every day » – 15 mill...
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