Alt.Immunity3BB

Alt.Immunity3BB

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Unformatted text preview: response destroys the RBC Produces response Targets of Hypersensitivity Targets Autoimmunity Autoimmunity Autoimmunity - breakdown of tolerance for selfantigens Possible causes of autoimmunity 1. Exposure of previously hidden antigens 2. Development of “neoantigens” • Haptens that bind to host proteins and then become antigenic 1. Complications of infectious disease • • Antigens from foreign microoraganisms Form immune complexes with host tissue Targets of Hypersensitivity Targets Autoimmunity Autoimmunity • Possible causes of autoimmunity (continued) 4. Emergence of a suppressed lymphocyte with a specificity Emergence for self-antigens for 5. Alteration in “suppressor T cells” • • • Suppressor T cell function is altered Suppressor T cells may block lymphocytes active against selfantigens Example - Systemic lupus erythematosus • Large populations of suppressor T cells are not functional Autoimmunity - Clinical Example Autoimmunity Systemic Lupus Erythematosis Defined - chronic, multi-system inflammatory disease – One of the most common autoimmune diseases Production of a variety of autoantibodies – – – – – Nucleic acids Erythrocytes Coagulation proteins Lymphocytes And many others Autoimmunity - Clinical Example Autoimmunity Systemic Lupus Erythematosis SLE incidence – – – Mostly in women (10:1) Ages 20 - 40 Blacks higher rate Vs whites (8 fold higher) Genetic link has been found Autoimmunity - Clinical Example Autoimmunity Systemic Lupus Erythematosis Autoimmunity - Clinical Example Autoimmunity Systemic Lupus Erythematosis Glomerular deposits result (see next fig) Increases in circulating DNA occurs normally – Tissue damage – Infections – Some drugs Increases deposition at the glomerulus – Due to more antibody-DNA complexes Autoimmunity - Clinical Example Autoimmunity Systemic Lupus Erythematosis Glomerular w/ antibody complexes A = glomerular cross section B = glomerulus glomerular basement membrane w/complexes Autoimmunity - Clinical Example Autoimmunity Systemic Lupus Erythematosis Clinical manifestations – – – – – Arthritis (90% of cases) Rash (70% - 80%) Anemia (50%) Cardiovascular (30% - 50%) Frequent remissions and exacerbations » Typical of autoimmune diseases – Multiple body symptoms - difficult to diagnose 11 Symptoms For Diagnosis 11 4 symptoms indicates lupus Facial rash (cheek) Discoid rash (raised) Photosensitivity as a Photosensitivity result of sun exposure result Oral ul...
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This note was uploaded on 04/18/2013 for the course BIO 205 taught by Professor Dr.cady during the Spring '11 term at Bradley.

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