Wright nat rev mol cell biol 172 76 2000 shortening

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Unformatted text preview: , Nat. Rev. Mol. Cell Biol. 1:72-76, 2000. Shortening of telomeric DNA with cell proliferation From C.M. Counter, F.M. Botelho, P. Wang et al., J. Virol. 68:3410-3414, 1994. Further shortening of telomeric DNA with crisis From C.M. Counter, F.M. Botelho, P. Wang et al., J. Virol. 68:3410-3414, 1994. Stabilization of Telomere length in immortal cells From C.M. Counter, F.M. Botelho, P. Wang et al., J. Virol. 68:3410-3414, 1994. Immortalized cells maintain telomeres by telomerase re-expression or Alternative Lengthening of Telomeres (ALT)! p53/pRb! ALT! Normal cells Premalignant cells Malignant cells Regulation of telomere length in normal and cancer cells by telomerase detection signaling p53 activation (often p53 deficient) SENESCENCE...
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