Lecture 17, Endo 18BB

2 2 suggested results in cell mediated destruction of

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: d at age 9 Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Two types of type I diabetes 1. 2. 2. – Suggested - results in cell-mediated destruction of B Suggested cells cells » B cells are insulin producing cells (pancreas) Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Common markers of immune destruction – Autoantibodies identified to …. » Pancreatic islet cells » Insulin » Glutamic acid decarboxylase (GAD) » HLA-DR3 markers (human leukocyte antigen) Glutamic Acid Decarboxylase (GAD) Glutamic Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I GAD – Enzyme in GABA production » Inhibitory neurotransmitter – GAD -– GABA function as paracrine factor in pancreatic islets – Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I General sequence of events in disease 1. 2. 2. 3. 3. 4. 4. 5. 5. Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Genetic susceptibility – HLA linked factor (histocompatibility antigens) » HLA-DR4 and HLA-DR3 alleles – HLA-DR4 (and DR3) - 5 - 8 fold higher risk of type I Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Long preclinical Period – Formation of islet cell autoantibodies (ICAs) – ICAs appear before islet destruction occurs » ICAs in 85 - 90% type I patients – ICAs suggested to be result of autoimmune process ICAs and not the cause and – Anti GAD antibodies extended presence in type I Dysf...
View Full Document

This note was uploaded on 05/02/2013 for the course BIO 205 taught by Professor Dr.cady during the Spring '11 term at Bradley.

Ask a homework question - tutors are online