Lecture 17, Endo 18BB

2 2 removing thyroid tissue removing thyroid tissue 1

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Unformatted text preview: tionale - control excessive TH 1. 2. 2. » removing thyroid tissue » removing thyroid tissue 1. Hyperthyroidism Hyperthyroidism Thyrotoxicosis - Graves Disease Thyrotoxicosis Graves Major cause of hyperthyroidism – Etiology - suggested as an autoimmune disease One or more of the following systems 1. 2. 2. 3. 3. 4. 4. Hyperthyroidism Hyperthyroidism Thyrotoxicosis - Graves Disease Thyrotoxicosis Graves Pathophysiology – – Thyroid autoantibodies (IgG) - 95% of Graves patients Hyperactivity of thyroid results in Hyperactivity » » Suppression of TRH Suppression of TSH » » Elevated iodine uptake at the thyroid Increase thyroid gland metabolism Hyperthyroidism Hyperthyroidism Thyrotoxicosis - Graves Disease Thyrotoxicosis Graves Pathophysiology - continued – Increased thyroid gland metabolism » » – Elevated iodine uptake at the thyroid Increases in thyroid vascularization and size Reasons for increases in thyroid hormone levels » Decreases in thyroid binding globulin » Less protein in serum to bind up TH results in more free TH (more TH Less in serum) in Increased production of thyroid hormone Hyperthyroidism Hyperthyroidism Thyrotoxicosis - Graves Disease Thyrotoxicosis Graves Symptoms continued – Pretibial myxedema - “Graves dermopathy” » Subcutaneous swelling anterior portions of legs Hyperthyroidism Hyperthyroidism Thyrotoxicosis - Graves Disease Thyrotoxicosis Graves Symptoms continued – Ocular symptoms - another autoimmune process is Ocular likel...
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