Lecture 17, Endo 18BB

Insulin levels at liver reducing dysfunction

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Unformatted text preview: ge and severity of disease Amyloid Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type II Hepatic lesions as fatty infiltrations – – – – Involved in increased risk factors Associated with obesity Associated Changes in portal blood flow (at liver) Changes Reducing insulin levels at liver Reducing Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type II In obesity – Insulin - lower ability to alter glucose uptake and Insulin metabolism metabolism » Liver, muscle and fat tissue Theory of cause - type II – Increases in insulin levels due to obesity Increases – Pancreas can’t sustain high levels of insulin Pancreas – May lead to peripheral insulin resistance May Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type II Treatment – Exercise and diet important aspect – Drugs » Hypoglycemic agents Sulfonylureas - enhance B cell insulin secretion » Biguanides - inhibit liver glucose production Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type II Treatment – Drugs (precase, glyset) » Alpha - glucosidase inhibitors Decrease hyperglycemia after meals Decrease Delaying carbohydrate digestion and absorption Delaying – Mechanism of action » In the small intestine glucosidase breaks down In carbohydrates into glucose carbohydrates » Inhibitors - therefore block glucose conversion from carbos » Delays glucose absorption at the intestine Dysfunction Endocrine Pancreas Dysfunction Diabetes Mel...
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