Lecture 17, Endo 18BB

Suppressor deficits suggested suppressors of immune

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Unformatted text preview: unction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Immunologicaly mediated destruction of B cells – Suggested that organ-specific suppressor deficits Suggested (suppressors of immune mechanisms) (suppressors » Lack of suppressors allows immune activate – May activate autoimmune responses Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Immunologicaly mediated destruction of B cells – Immune system cells attack the islets – Environmental toxins may enhance susceptibility of Environmental islets to immune attack islets Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Hyperglycemia – Before hyperglycemia - symptoms » 80 - 90 % of β cells lost 80 – » Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Glucagon – Stimulates gluconeogenesis at the liver » Increases glucose levels – Enhances onset of hyperglycemia – Overproduction of glucose and ketones in Overproduction uncontrolled type I uncontrolled Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Clinical aspects to diabetes – Glucose accumulates in the blood – Glucose appears in the urine » – Results in osmotic diuresis » Loss of water Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Clinical aspects to diabetes (continued) – Diuresis results in » Polyuria » Excessive thirst – Weight loss due to breakdown of fats and proteins Dysfunction Endocrine Pancre...
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This note was uploaded on 05/02/2013 for the course BIO 205 taught by Professor Dr.cady during the Spring '11 term at Bradley.

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