Lecture 17, Endo 18BB

Than 30 from fats 15 20 from proteins dysfunction

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Unformatted text preview: dema Side effects rare w/ human recombinant insulin Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Treatment options Diet – – – – Requires enough calories to maintain normal weight 55 - 60% total calories from carbohydrates Less than 30% from fats 15 - 20% from proteins Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type I Treatment options Transplantation Transplantation – Pancreatic transplantation since 1966 » Normal glucose maintained for 5 yrs – Rejection of transplant tissue » Immunosuppression drugs Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type II Type Type II - most common form – Cause - unknown Patients primarily after 40 years of age – Mostly obese individuals Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type II Increased risk of type II with obesity – 80 - 90% of patients with type II Characterized by Insulin resistance Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type II Defining insulin resistance – Lower response of insulin-sensitive tissues » » » Liver Liver Muscle Muscle Adipose tissue Adipose Dysfunction Endocrine Pancreas Dysfunction Diabetes Mellitus - Type II During progression of the disease β cells become unresponsive to changes in glucose levels levels – Leading to hyperglycemia – Amyloid formations on the islets » » » High ROS stress at islets - amyloid High Induces apoptosis in β cells Amyloid directly correlated w/ a...
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