3-6-13_germ cells and germ plasm

17 j b walsh genetics 139 421 1995 18 m kreitman

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Unformatted text preview: 1996). 17. J. B. Walsh, Genetics 139, 421 (1995). 18. M. Kreitman, J. M. Comeron, Curr. Opin. Genet. Dev. 9, 637 (1999). 19. B. Y. Liao, J. Zhang, Trends Genet. 23, 378 (2007). 20. T. Makino, K. Hokamp, A. McLysaght, Trends Genet. 25, 152 (2009). 21. Z. Su, X. Gu, J. Mol. Evol. 67, 705 (2008). 22. H. Liang, W. H. Li, Trends Genet. 23, 375 (2007). 23. Z. Gauhar et al., Personal communication to FlyBase, FBrf0205914: Drosophila melanogaster life-cycle gene expression dataset and microarray normalisation protocols (2008); http://flybase.org/reports/FBrf0205914.html. 24. J. A. Williams, S. W. Paddock, S. B. Carroll, Development 117, 571 (1993). 25. C. D. Jones, D. J. Begun, Proc. Natl. Acad. Sci. U.S.A. 102, 11373 (2005). 26. B. Loppin, D. Lepetit, S. Dorus, P. Couble, T. L. Karr, Curr. Biol. 15, 87 (2005). 27. L. Giot et al., Science 302, 1727 (2003). 28. S. Griffiths-Jones, Methods Mol. Biol. 342, 129 (2006). 29. M. Lynch, M. O’Hely, B. Walsh, A. Force, Genetics 159, 1789 (2001). 30. We thank C. H. Langley and D. Begun for providing polymorphism data; W. Du, J. Gavin-Smyth, Q. Guo, and M. Guffey for technical assistance and discussion; J. Coyne, M. Kreitman, and X. Ni for critically reading and/or revising the manuscript; and the members of the Manyuan Long laboratory, C. Ferguson, R. Hudson, C. I. Wu, and T. Nagylaki, for valuable discussion. S.C. was supported by University of Chicago Biological Sciences Division Fellowships. This research was supported by National Institutes of Health (R01GM065429-01A1 and R01GM078070-01A1) and National Science Foundation (CAREER Award MCB 0238168) to M.L. Y.E.Z. was also supported by the Searle Funds from Chicago Biomedical Consortium (2009, Spark). in all germ cells except mature sperm, and they segregate asymmetrically with the germline pre- www.sciencemag.org SCIENCE VOL 330 P granules PIE-1 is in the cytoplasm of P1 and later germ cell precursors Downloaded from www.sciencemag.org on March 7, 2011 We finally investigated the viability phenotype of the parental genes with available RNAi lines (table S10) and retrieved the phenotypic information of several additional genes from previous studies (10...
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