4c. Viruses - 4. Microorganisms as Pathogens: Viruses...

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    4. Microorganisms as Pathogens: Viruses
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    2 Viruses as Pathogens Historical Perspective Virology - Historical Perspective 1892 Iwanowski studied tobacco mosaic disease used porcelain filter capable of trapping the smallest bacteria filtered crushed afflicted leaves infectious agent passed through filter reported that a filterable virus was the agent of disease soon others found filterable viruses as agents of specific diseases early 1900’s viruses that infect bacteria were discovered termed bacteriophage (bacteria eaters)
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    3 Viruses as Pathogens Historical Perspective 1930’s nucleic acid and protein nature of viruses was discovered Woodruff and Goodpasture fertilized chick embryos used for animal virus propagation (living analog of Koch’s nutrient agar) Stanley - virus could be crystallized insight into their simplicity began debate regarding living nature of viruses lifeless (similar to crystalline chemical molecule) vs. living (replicates, induced fevers, stimulates antibody production - not associated with chemical molecules) 1940’s - two significant developments electron microscope - allowed visualization of viruses tissue culture - Enders, Weller and Robbins
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    4 Viruses Survey Survey of Viruses responsible for many human diseases, including: influenza hepatitis polio rabies chickenpox AIDS mycobacteriaphage vaccinia polio adenovirus tomato bushy stunt virus
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    5 Viruses Classification
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4c. Viruses - 4. Microorganisms as Pathogens: Viruses...

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