Lecture06-17Apr13 (1) - BIS 101 17 Apr 13 Gene Interactions Genetic Linkage Analysis Genetic Mapping Midterm I Review Session Tuesday Apr 23 6:10-8:00

Lecture06-17Apr13 (1) - BIS 101 17 Apr 13 Gene Interactions...

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BIS 101 17 Apr 13 Gene Interactions Genetic Linkage Analysis Genetic Mapping Midterm I Review Session: Tuesday Apr. 23, 6:10-8:00 pm Giedt 1002 Draper Extra Office Hour: Tuesday Apr. 23, 1:00-3:00 pm Life Science 3002 1
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No gene interaction (9:3:3:1) Two genes, independent pathways. 9: b + _; o + _ 3: b + _;oo 1: bb;oo 3: bb; o + _ B + b;o + o X b + b; o + o b + = Black o + = Orange 2
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Complementary Gene Interaction (9:7) 3
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Gene Functional Redundancy (15:1) 4 Tail Phenotype 9/16 3/16 wild-type tail 3/16 1/16 mutant tail fgf8 and fgf24 are redundantly required for tail formation in zebrafish
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Recessive Epistasis (9:3:4) 9: B_;E_ 3: bb;E_ 3:B_;ee + 1:bb;ee Two genes, in dependent pathway. 5
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6
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7 “.” indicates identical amino acid “*” indicates sequence not determined Brown Yellow DNA(codon) C GA T GA Amino Acid Arg Stop
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Dominant Epistasis (12:3:1) Two genes in dependent pathway.
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  • Winter '13
  • Kramer
  • Genetic linkage, Genetic Linkage Analysis

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