BSCI DNA Structure - fldenine I.33 N Nil" ‘” 5C 3C...

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Unformatted text preview: fldenine I .33. N Nil" ‘” 5C 3C Hag: 3 _:m..____-‘3 .~_~_.N,, N D | 5' ‘D—P—D—CHE D Phosphate Adennsine 5'-munuphusphate {AMP} OH OH OH H Ribnse 2-Denxyrihnse fi'l'ltallbflmw-Hil [it-minus; hp. Permission mire-dim raplc-chniicrnarflplay. DNA's chemical constituents, part 2 (b) Assembly intn a nucleutide HID Nucleuside Purine Pyrimidine nucleutide nucleutide fi'l'helibfllaw-Hil [it-{maths he. Femiaaien reunite-die: replc-chsiienerflplay. DNA's chemical constituents, part 1 (a) The separate entities 1 . Deexyribese sugar HDCH DH H H 3. Feur nitregeneus bases Purines Adenine {A} a II a as x“ H— a E: H M “NH: Guanine {G} Pyrimidines Cytesine {C} PUHINES '7‘”? Nf’ ir: H Héfifia'fixgr’f N | H Adenine {A} I ma K4 9;” Guanine {G} PYRIMIDINES Naming Nuclunsidui and Huclmt'tdcs Bases Purim Uracil I'L'I rhlrninr {Ail Guanim: [£1] Kym-sin:- [fl] Thymim: [T] ,4 file Hide: "1 RNA Adennsme flummsine Cfr'Ildlfl-E' Uridine ' u E ' ll'. HHA lh'tnj-Jclrzlnrnzlc lT'L':W}_:LL:1IH:-~.II1L' |-:'L":Z"'.f-'IL:-1l.:.l1|:' I‘l'unxnyihj-IIII-LIHIL' w l .d in RNA r‘Liltngrlnn: (£11311?an CyTi-{lylntc L'ridjr'lntr ' H: mm :5 in NEW. ['JL'iI-H':s'.?|-.|:"1:n-'|.1|'-!" ['Jz-Iwuj-‘jillnnyla'rc' Huh::-'-.'j.'t':-'Ti::j.'|.1n' '[II1‘.'|"Ii-.|:-'|.=.r-:" Nuclmcsidr munuphnsphatcs AMP (3MP CMP UMP Huck-aside diplmsphates ADP III-"DP EDP UDF‘ NUCIEE'HSZidE triphufiphatfl HI'P Il'.'i'['J“ {II'I'J‘ lJ'H‘ I'hu:-'-.'f.'1IL|-.'|:-c:-.i:ir I11-::-ncJ-. din :1an Trinh-mplutm; L|.-'I.f"..'.|L L-rg. 3' and fi'l'hallbflmw-Hil Bombs; hp. Panflaaicrn mire-dim raplc-chniicrnarflplay. The structure of DNA, I 31 5' Axle afhalix . Eu ar—phnsphata .. ban: bane 3.4 A fi'l'hallbflmw-Hil Bombs; hp. Panflaaicrn mire-dim raplc-chniicrnarflplay. . J" In . Mlnflr gran“ ' II ,. Base Fall's Majur granule I / E Base pairs l—l Sugar-phusphate hackbnne A FIGURE 4-6 Two representations of the DNA double helix. (a) Chemical structure of double-helical DNA, unraveled to show the sugar—phosphate backbones (black), base-paired bases (blue and red), and the hydrogen bonds between the bases (red dotted lines). The backbones run in opposite directions; the 5’ and 3’ ends are named for the orientation of the 5’ and 3’ carbon atoms of the sugar rings. Each base pair has one purine basewadenine (A) or guanine (Gl—and one pyrimidine base—thymine (T) or cytosine (C)— connected by hydrogen bonds. lb) Skeletal model of double- helical DNA. The deoxyribose sugar rings and bases in one strand are shown in red, and in blue in the other strand; the phosphodiester bonds are black. The sugar—phosphate back— (b) 5' 3’ 3.4 nm 0.34 nm 3’ 5’ bone is on the outside of the double helix, while the bases (shown on edge) project inward and are stacked in parallel "rungs," 0.34 nm apart. In the most common form of DNA (the B form), each strand makes a complete 360° turn every 3.4 nm. [Part (a) from R. E. Dickerson, 1983, Scientific Amer- ican, 249(6):94—1ll. Part (b) from L. Stryer, 1988, Biochemis— try, 3d ed., W. H. Freeman and Company, p. 77.] Thymine Adenine denxyfibnse denxyfibnse Guanine Cytasine [C] 2 DNA {:1} Triple-Helical DNA [N A DNA [a] EDNA fi'l'ltallbfltaw-Hil normalise. he. Permission reunite-dim replc-chsiicrnarflplay. The structure of RNA {a}The separate entities ‘ {h} Assembly inta a ‘ {a} thunudantidaa juln 1-1.“ Bu an Him“ rihanueleatlde ta term a slngle strand instea at deexyrlhacse 3| . s at rlhanueleetides 2. A phesphate group "i‘ 'n— P-e c'. 3. The teur bases CI H H H Urasll {U} Instead at thymlne {T} Plus Adenine, IGuanine, Cyteslne ta} Amino acid {alanine} Thane ptm stern ________ _____a- lb} WEE Incap- D Imp 1u'ariatmle luop Acceptor stern Antimdun loop {a} Secondary structure Duuble-helical stem reginn _ # Stem-loop Hairpin {b} TertiaryF structure _3' Folding #3? Pseuduknut ...
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