Lecture 11 (Sept 24)

Lecture 11 (Sept 24) - Biological Sciences 110A:...

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Lecture 11: Overview of metabolism  Introduction to metabolism  Review of oxidation (redox potential)  Convergent catabolic pathways  Feedback regulation of glycolysis  Glycolysis versus gluconeogenesis Biological Sciences 110A: Introduction to Biology Kendal Broadie Reading in Chapter 3 (107-116) Karp
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Metabolism : The cycle of photosynthesis and respiration
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Energy stored as  high-energy  phosphates The average human  produces/consumes 2 X10 26 molecules (>160 kg = >350  lbs) of ATP per day!
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Cells oxidize sugars in a step-wise fashion A great deal of ATP  (∆G = +7.3)
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Oxidation of reduced organic molecules liberates high energy  electrons Oxidation : losing electrons  (gain O or lose H)  Reduction : gaining electrons  (gain H or lose O) Cells use NADH as an electron source/storage molecule for reduction/oxidation reactions more stored energy less stored energy See Fig. 3.22 Karp
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Cells store “high energy” electrons (e - ) in NADH Energy stored as high-energy  electrons See Fig. 3.26 Karp
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The harvest of energy occurs in two compartments: Cytosol and  Mitochondria nucleus mitochondria protein filaments in the  cytosol cultured mammalian fibroblast
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Lecture 11 (Sept 24) - Biological Sciences 110A:...

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