Lecture 13 (Sept 28)

Lecture 13 (Sept 28) - Biological Sciences 110A:...

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 Structure of the mitochondrion  Electron transport; electron carriers  Proton pumps in the inner mitochondrial membrane  Redox potential (mV) and free energy change (∆G)  Proton motive force: pH + voltage (mV)  ATP synthesis machinery (ATP synthase)  Balancing the books; a final accounting Biological Sciences 110A: Introduction to Biology Kendal Broadie Reading in Chapter 5 (189-206) Karp
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Harvesting energy from food: overview of cell metabolism S ta g e  1 :  Bre akdo wn o f la rg e  m a c ro m o le c ule s  to   s im ple  s ub units  o c c urs  o uts ide  c e lls  (e .g . s to m ac h) S ta g e  2 :  Bre akdo wn o f s im ple  s ug a rs  to   ac e tyl-C o A,  a   s m a ll e ne rg y harve s t ( ATP and NADH ) 1.   Glycolysis  (g luc o s e  to  pyruvate )  in c yto s o l 2. Pyruva te  to  ac e tyl-C o A in m ito c ho ndria S ta g e  3 :  Fina l o xida tio n o f ac e tyl-C o A to  H 2 O, CO 2  in  mitochondria, large energy harvest ( ATP, NADH ) 1.  Citric acid cycle    (a c e tyl-C o A to  C O 2  waste) is  us e d to  pro duc e   ATP and NADH 2.   Oxidative phosphorylation  ( NADH to  ATP us ing  O 2  and releasing H 2 O as waste Same oxidation cycle for all Fats  are  b ro ke n do wn by  β - o xidatio n , fe e ding  a c e tyl-C o A into  the  c itric  a c id c yc le .  Am ino  a c ids  de rive d fro m   proteins  e nte r this  pa thwa y  a t s e ve ral po ints .
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Finally, we come to O 2  consumption: oxidative phosphorylation
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Lecture 13 (Sept 28) - Biological Sciences 110A:...

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