VUBio110BSp'08-GeneticVariation-HW 8-POST

VUBio110BSp'08-GeneticVariation-HW 8-POST - Deriving...

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Deriving Hardy-Weinberg Equilibrium p 2 + 2pq + q 2
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Predictive value of Hardy-Weinberg Genetic diseases Can determine frequency of carriers (heterozygotes) which “keep” lethal alleles in the population e.g. PKU and Cystic fibrosis Predicting frequencies of x-linked traits require additional consideration
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X-linked frequencies Males only carry one copy of X, so the genotypic frequency = allele frequency e.g., Red-green colorblindness 1/25 males – q m = 0.04, p m = 0.96 (and no heterozygotes) Females conform to H-W, so p 2 + 2pq + q 2 represents female genotypic frequencies
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What keeps a population in equilibrium? (Assumptions of H-W) Mating is random No mutations The population is very large The population is isolated No natural selection
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Hardy-Weinberg equilibrium A mathematical guideline to which real populations are compared to detect change If allele frequencies change over time, the population is evolving MICROEVOLUTION
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This note was uploaded on 04/07/2008 for the course BSCI 110B taught by Professor Due during the Spring '08 term at Vanderbilt.

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VUBio110BSp'08-GeneticVariation-HW 8-POST - Deriving...

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