VUBio110B-Sp'08-Mendelian Genetics 3-Prob thru pleiotropy-Posted

VUBio110B-Sp'08-Mendelian Genetics 3-Prob thru pleiotropy-Posted

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Predictions of Mendelian Genetics are based on rules of probability Multiplication rule Chance of getting this AND this Addition rule Chance of getting this OR this
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Incomplete Dominance • F 1 exhibits unexpected phenotype (intermediate to both parents)—Blending? Phenotype indicates genotype Phenotypic and genotypic ratios the same
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Hypercholesterolemia
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Human ABO blood type Heterozygote exhibits unexpected phenotype (both traits A & B equally expressed) BUT, O is recessive to A and B What’s going on?
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Codominance and Multiple Alleles
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Unformatted text preview: ABO blood type exhibits codominance and multiple alleles http://sevencastles.spaces.live.com/blog/cns!7C5A2F3DB6C97D9A!7326.entry Multiple alleles may exhibit a hierarchy of dominance Major Histocompatability Complex - highly polymorphic and codominant http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=imm.figgrp.581 http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Transplants.html Pleiotropy (e.g., sickle cell anemia) http://fig.cox.miami.edu/~cmallery/150/gene/14x15sickle.jpg...
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VUBio110B-Sp'08-Mendelian Genetics 3-Prob thru pleiotropy-Posted

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