Regulatory T cells - • Signal is strengthened by CD28 and...

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Regulatory T cells (TR) (Treg) CD4+CD25+ Foxp3 cells are the best characterized Actively suppress immune responses 1. Develop in the thymus and express CD4, CD25, and Foxp3 (CD4+CD25+Foxp3+). This population is called naturally occurring Treg. 2. Can be generated in the periphery. This population is referred as inducible Treg. 3. Suppress the response of effector T cells in the periphery. 4. Controls autoimmune reactivity of T cells by inhibiting immune responses directed against self antigens. 5. Involved in manipulation of lymphocyte homeostasis 6. Mice deficient in Treg exhibit several immune pathology Treg cell lineage specification by Foxp3   In the thymus: • DP with high-avidity TCR interacting with MHC/self peptide
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Unformatted text preview: • Signal is strengthened by CD28 and an additional, unidentified signal • Induces Foxp3 expression • Treg cell lineage commitment In the periphery: • Production of IL-2 by T cells expands the Treg cell population. • Treg cells control T cell self-reactivity and autoimmune inflammation. • Treg cells can downmodulate inflammation associated with pathogen-specific immune responses Cellular targets of Foxp3+ Treg cell-mediated suppressor function CD4+, CD8+ T cells Dendritic cells B cells Macrophages Osteoblasts Mast cells NK cells NKT cells When Treg cells are not present…. . with Treg without Treg...
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