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Unformatted text preview: • Signal is strengthened by CD28 and an additional, unidentified signal • Induces Foxp3 expression • Treg cell lineage commitment In the periphery: • Production of IL-2 by T cells expands the Treg cell population. • Treg cells control T cell self-reactivity and autoimmune inflammation. • Treg cells can downmodulate inflammation associated with pathogen-specific immune responses Cellular targets of Foxp3+ Treg cell-mediated suppressor function CD4+, CD8+ T cells Dendritic cells B cells Macrophages Osteoblasts Mast cells NK cells NKT cells When Treg cells are not present…. . with Treg without Treg...
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- Fall '09