Lecture 10 2 slides page

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Unformatted text preview: n the gene for CFTR that causes the retenCon of the CFTR protein in the ER by the Quality Control System LocaCon of Normal CFTR Mutant CFTR Does not leave ER CFTR: CysCc Fibrosis Transmembrane Conductance Regulator – it is a Cl- channel normally found in the plasma membrane Figure 15-18 Essential Cell Biology Today’s topics 1.  Events in the ER: Protein glycosylaBon, protein folding and protein Quality Control 2.  Transport by vesicles to the Golgi Apparatus: COPII 3.  Protein modificaBon in the Golgi, and transport out of it. 5 2/24/13 The Secretory Pathway and Protein SorCng Nucleus ER ‘resident’ protein Protein to be secreted out of cell Protein to be delivered to the lysosome Nuclear envelope Rough ER Transport vesicles Golgi Transport vesicles 1µm Figure 13-25b M...
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This note was uploaded on 05/17/2013 for the course BIOMG 1350 taught by Professor Bretscher during the Spring '12 term at Cornell University (Engineering School).

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