Several ubiquien molecules can be covalently linked

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Unformatted text preview: t another site KINASE ACTIVITY OFF ON two inhibitory phosphates AcEvaEng protein phosphatase Figure 17-25 Molecular Biology of the Cell Julie Cdk Movie 8 3/3/13 Structural basis of Cdk acEvity Figure 17-17 Molecular Biology of the Cell Cyclin levels rise gradually but Cdk acEvity rises abruptly inhibitory phosphate AcEvaEng phosphatase AcEvaEng phosphatase Figure 18-9 Essential Cell Biology 9 3/3/13 The acEvaEon of M- Cdk KINASE ACTIVITY OFF ON two inhibitory phosphates Figure 17-25 Molecular Biology of the Cell Cyclin levels and Cdk acEvity drop abruptly Figure 18-4 and 18-5 Essential Cell Biology 10 3/3/13 Cdk inacEvaEon is triggered by cyclin degradaEon UbiquiEn is a small protein. Several ubiquiEn molecules can be covalently linked to proteins (‘poly- ubiquitylaEon’). Poly- ubiquitylaEon of a protein is a common signal in cells that marks the protein for destrucEon in a structure called the proteasome. Figure 18-11 Essential Cell Biology The ordering of events in the cell cycle is controlled by checkpoints and acEvaEon of cyclin dependent kinases (Cdks) Figure 18-1, 18-3 combined Essential Cell Biology 11 3/3/13 Today’s topics 1.  The cell cycle is divided into four phases. 2.  The...
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This note was uploaded on 05/17/2013 for the course BIOMG 1350 taught by Professor Bretscher during the Spring '12 term at Cornell University (Engineering School).

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