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Lecture 24_13 2 slides

Lecture 24_13 2 slides - Stem cells the source of future...

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4/28/13’ 1’ Stem’cells’--’the’ source’of’future’ medical’ miracles?’ 1. Know’that’adult’stem’cells’provide’a’source’of’cells’for’maintenance’and’ repair’of’adult’±ssues.’ 2. Understand’the’plas±city’of’ blastomeres’in’early’mammalian.’ 3. Understand’that’early’mammalian’ blastomeres’can’be’ propageted’in’ culture’and’retain’their’capacity’to’develop’into’any’cell’type’in’the’ organism.’ 4. Understand’that’expression’of’a’small’number’of’transcrip±onal’ regulators’can’reprogram’diFeren±ated’cells’to’become’pluripotent’ stem’cell-like’cells’(induced’pluripotent’stem’cells’or’IPSCs.’ Course’evalua±ons:’ ’ 1)’Dr.’ Bretscher’ ’ 2)’Dr.’Kemphues’ ’ 3)’Your’Ac±ve’Learning’Sec±on’TA’ To’get’credit’for’doing’it,’make’sure’you’do’ it’by’the’day’a²er’the’³nal’exam.’
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4/28/13’ 2’ V D V D Dorsal lip TGF- β family Uniform’ BMP4’ expression’ How do organisms maintain .ssues and organs? 1. Adult’Stem’cells’ 2. Embryonic’stem’cells’ 3. Therapeu?c’cloning’ 4. Induced’pluripotent’stem’cells’
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4/28/13’ 3’ Adult’ stem cells ’generate’a’ con?nuous’supply’of’ terminally’diFeren?ated’ cells.’ Well-studied’examples:’ Skin’stem’cells’ Intes?nal’stem’cells’ Hematopoe?c’stem’cells’ Neuronal’stem’cells’
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4/28/13’ 4’ The’lining’of’the’ intes?ne’is’ constantly’renewed’ via’stem’cells’that’ reside’in’the’crypts’ between’the’ intes?nal’ villi.’ Stem’cells’reside’in’ stem cell niches ’that’via’signaling’ maintain’the’iden?ty’of’ stem’cells.’Other’signals’ control’the’rate’of’cell’ division’of’the’stem’cells’and’ precursor’cells.’
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