CMA & CBA - Cost-Minimization Analysis...

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Cost-Minimization Analysis
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Cost-Minimization Analysis Definition: a pharmacoeconomic tool for comparing all relevant costs and consequences of two or more therapeutic interventions that are equivalent. The objective is to choose the least costly alternative among equivalent or equally efficacious alternatives.
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Example: Comparisons between brand and generic products; different route of administration of the same drug; and different settings for administration of the same drug (inpatient vs. home therapy).
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Cost-Minimization Analysis comparisons of alternatives with equivalent outcomes only; equivalent outcomes mean similar results measured in natural units; quality-adjusted life years or other quality-of-life measures (CUA); or monetary measures (CBA).
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Example: Generic or brand analgesics have similar outcomes: pain relief or no pain relief Example: Oral or injectable antibiotics have similar outcomes: treatment success or failure
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How do you establish equivalency: brand and generic - use the Approved Drug Products with Therapeutic Equivalence Evaluations - “orange book” between products in a similar therapeutic class - use meta-analysis, an analytical technique of systematically combining results of many studies to reach a conclusion of the overall effect.
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What about two or more alternatives that are not exactly equivalent? Example: Antibiotic A that is 80% effective and Antibiotic B that is 98% effective? When outcomes are measurable in exact categories, like Yes/No or Success/Failure , they can be easily confirmed as equivalent.
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Other types of pharmacoeconomic evaluations are necessary when outcomes are measured along a continuum or quantitatively. Example: Beta Blocker vs. Ace Inhibitors vs. Calcium Channel Blockers vs. Diuretics for the treatment of hypertension; outcomes - mm Hg decrease in blood pressure
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Efficacy measures of the outcomes in a controlled environment (clinical trial). Effectiveness
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This note was uploaded on 04/07/2008 for the course PAS 2201 taught by Professor Dhing during the Spring '07 term at St. Johns Duplicate.

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CMA & CBA - Cost-Minimization Analysis...

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