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Principles & Problems - Principles Problems Important...

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    Principles & Problems: Important Building Blocks for  Pharmacy Students Danielle C. Ezzo, Pharm.D., BCPS St. John’s University [email protected] 718-990-1886
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    Principles of  Pharmacotherapy
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    Definition - Literally Pharmacotherapy Treatment of disease through the use of drugs
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    Definition - Extended Pharmacotherapy… …is that area of pharmacy practice that ensures the safe, appropriate, and economical use of medications.
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    Journals The Annals of Pharmacotherapy www.theannals.com Pharmacotherapy www.pharmacotherapy.org
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    Guiding Principles of Pharmacotherapy “Dipiro’s” Pharmacotherapy: A Pathophysiologic Approach Joseph T. Dipiro (author)
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    Guiding Principle… There should be a justifiable and documented indication for every medication that is used.
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    Guiding Principle… A medication should be used at the lowest dosage and for the shortest duration that is likely to achieve the desired outcome.
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    Guiding Principle… When a patient is adequately treated with a single drug, monotherapy is preferred.
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    Guiding Principle… Newly approved medications should be used only if there are clear advantages over older medications. Example: Neurontin® vs. Lyrica®
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    Guiding Principle… Whenever possible, the selection of a medication regimen should be based upon evidence obtained from controlled clinical trials.
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    Guiding Principle… The timing of drug administration should be considered as a possible influence on drug efficacy, adverse effects, and interactions with other drugs.
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      A medication regimen should be simplified as much as possible to enhance patient adherence. Example: Immediate release vs. extended release Guiding Principle…
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    Guiding Principle… A patients’ perception of illness or the risks and benefits of therapy may affect adherence and treatment outcomes. Examples: Flu High blood pressure
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    Guiding Principle… Careful observation of a patient’s response to treatment is necessary to confirm efficacy, prevent, detect, or manage adverse effects, assess compliance, and determine the need for dosage adjustment or discontinuation of drug therapy.
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    Guiding Principle… A medication should not be given by injection when giving it by mouth would be just as effective and safe.
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