L 5 & 6 - PPT Fungal Structure

Macrophage cryptococcus encapsulated cryptococcus

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Unformatted text preview: psulatum Yeast within macrophage Cryptococcus (encapsulated) Cryptococcus Pseudohypha (elongated yeast cell) Budding yeast Germ Tube elongated appendage growing from yeast cell Virulence adherence penetration (proteases) Germ tube A patient who is being treated for a malignancy develops sores of the mouth and lips. Lab culture produces microscopic cells as shown. What is the causative agent? io id e ci d oc 5C is t 0% s m a 0% op la s di da 4H sp 2A 0% an er gi ll us oc c to c ry p 0% us 0% 3C Cryptococcus Aspergillus Candida Histoplasma Coccidioides 1C 1 2 3 4 5 30 Molds Molds Hypha long strand or filament of cells Hypha Hypha Filament of cells As observed in lab & biopsy specimens Septate hyphae Aspergillus—septate Rhizopus, Mucor—nonseptate Tissue biopsy from a patient w/ diabetic ketoacidosis reveals nonseptate hyphae. The most likely causative agent is: io id e s 0% oc ci d to m yc 5C 4B la s an pu s 0% es 0% di da 0% hi zo 2R sp er gi ll us 0% 3C Aspergillus Rhizopus Candida Blastomyces Coccidioides 1A 1 2 3 4 5 30 Mycelium Mycelium mat of hyphae Asexual Spores Spores (Asexual Reproduction) Sporangiospore within sporangium Conidium from conidiophore Sporangium Sporangium Sporangiophore — stalk that bears sporangium sporangium sporangiospore Fungal Structure sporangiospores Fungal Structure Conidium Conidium Conidium asexual fungal spore Conidiophore hypha branch that bears conidia Fungal Structure conidium phialide conidiophore hypha Penicillium Aspergillus Conidial Examples Arthroconidium hypha fragmenting Blastoconidium by budding Chlamydoconidium swollen hypha Arthrospores Arthrospores Arthrospores Tissue from a skin scraping, cleared in 10% KOH, reveals fungal structures as illustrated. What are these structure? Germ tubes Blastospores Pseudohyphae Arthrospores Chlamydospores os po hl am yd 5C 0% re s re s 0% po e rth ro s 4A ud oh se 3P 0% yp ha po re s 0% to s la s 2B er m tu be s 0% 1G 1 2 3 4 5 30 Blastoconidia Chlamydoconidia Blastospores Chlamydospores Additional Conidial Examples Microcondium unicellular Macroconidium multicellular Microconidium Macroconidium Dermatophytes Macroconidia—Microsporum Microconidia—Trichophyton Microsporum macroconidia Classification Classification Based on sexual & Asexual stages Imperfect Fungi Imperfect no recognized or existing sexual reproductive stage Perfect Fungi recognized sexual stage Pathogenicity & Pathogenicity Disease Classification Mycosis Mycosis funga...
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