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Criteria for diagnosing dm type 1 dm is diagnosed by

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Unformatted text preview: lops type 2 DM, the If chances of the second sibling developing DM is close to 100%. • Criteria for diagnosing DM – Type 1 DM is diagnosed by a random blood glucose ≥200 mg/dL Type plus symptoms of DM e.g. polyuria, polydipsia or unexplained weight loss – Type 2 DM is diagnosed when fasting plasma glucose ≥126 Type mg/dL is seen on two or more occasions Module #1 Module Exam #2 Diabetes, Lecture #21 7 Signs and Symptoms of Type 1 DM • Type 1 DM can occur at any age but usually presents <30 years of age. age. • • • Average age at onset 16 Average The lack of insulin results in hyperglycemia and ketoacidosis Patients usually present with the three ‘Ps’; polyuria, polydipsia and Patients polyuria, polyphagia. Clinical presentation is often triggered by stress. Clinical – Stress prompts the release of epinephrine which inhibits insulin release Stress inhibits and action thus accentuating the problem and thus • Hyperglycemia results in large amounts of glucose being filtered at the at kidney kidney – When the rate of renal glucose filtration exceeds the rate of tubular bular reabsorption, glucose will appear in the urine • Large amounts of glucose in the urine prevents water reabsorption and and • • this increases urine volume (polyuria) leading to dehydration this Increased urination will result in polydipsia Increased polydipsia Low insulin levels trigger polyphagia Low polyphagia Module #1 Module Exam #2 Diabetes, Lecture #2...
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