Unformatted text preview: lops type 2 DM, the
chances of the second sibling developing DM is close to 100%. • Criteria for diagnosing DM – Type 1 DM is diagnosed by a random blood glucose ≥200 mg/dL
plus symptoms of DM e.g. polyuria, polydipsia or unexplained
– Type 2 DM is diagnosed when fasting plasma glucose ≥126
mg/dL is seen on two or more occasions Module #1
Exam #2 Diabetes, Lecture #21 7 Signs and Symptoms of Type 1 DM
• Type 1 DM can occur at any age but usually presents <30 years of age.
• Average age at onset 16
The lack of insulin results in hyperglycemia and ketoacidosis
Patients usually present with the three ‘Ps’; polyuria, polydipsia and
Clinical presentation is often triggered by stress.
Clinical – Stress prompts the release of epinephrine which inhibits insulin release
and action thus accentuating the problem
thus • Hyperglycemia results in large amounts of glucose being filtered at the
kidney – When the rate of renal glucose filtration exceeds the rate of tubular
reabsorption, glucose will appear in the urine • Large amounts of glucose in the urine prevents water reabsorption and
• this increases urine volume (polyuria) leading to dehydration
Increased urination will result in polydipsia
Low insulin levels trigger polyphagia
polyphagia Module #1
Exam #2 Diabetes, Lecture #2...
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- Fall '08
- Diabetes, Type 1 Diabetes Mellitus