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Diabetes mellitus dm is a heterogeneous group of

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Unformatted text preview: cture #21 3 What is Diabetes Mellitus? • Diabetes mellitus (DM) is a heterogeneous group of Diabetes • syndromes characterized by hyperglycemia and caused by: syndromes – An absolute deficiency of insulin, type 1 DM – Ineffective insulin (aka insulin resistance), type 2 DM The incidence (cases/year) of type 1 and 2 diabetes in the US are 30,000 and 625,000 (Less than 10% of the diabetics in the US have 30,000 type 1 DM) type – The incidence and prevalence of type 2 is increasing because of the The increase in obesity, sedentary lifestyle and aging of the US population increase ulation • DM is the major cause of adult blindness and amputation and a DM significant cause of periodontal disease, renal failure, heart attacks significant ttacks and strokes. and Module #1 Module Exam #2 Diabetes, Lecture #21 4 Diabetes Mellitus is a Multifactorial Disease • Type 1 DM is a “multifactorial disease” iin which an environmental n Type • • • • factor (e.g. a viral infection) and a genetic component (e.g. a mutation in the immune system) results in the body recognizing βcells as “non-self...
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