Epinephrine is high due to the metabolic stress

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Unformatted text preview: n 25 to 40% of newly diagnosed type 1 diabetics Ketosis 25 High epinephrine and very low insulin leads to an accelerated rate of High lipolysis. (Epinephrine is high due to the “metabolic stress” caused by lipolysis (Epinephrine caused the lack of insulin) the The carnitine shuttle is extremely active because of no insulin. The carnitine because This leads to an acceleration of β-oxidation and ketogenesis (ketosis) • Diabetic ketoacidosis (DKA) occurs when a patient with ketosis Diabetic develops dehydration secondary to polyuria. dehydration – Dehydration prevents the kidney from excreting the hydrogen ions formed formed by ketone bodies (ketone bodies are acids), thus leading to acidosis by Module #1 Module Exam #2 Diabetes, Lecture #21 11 Dehydration *Glucagon levels are only elevated in the “uncontrolled diabetic” early on in the disease process Module #1 Module Exam #2 Diabetes, Lecture #21 12 Metabolic Changes in Type 1 DM Hypertriglyceridemia • Hypertriglyceridemia in uncontrolled type 1 DM is due to: • Increased synthesis of triacylglycerol (the (the • accelerated lipolysis seen in uncontrolled type 1 DM accelerated seen results in a huge excess of free fatty acids which the liver reesterifies to glycerol phosphate to form triacylglycerol) Decreased level of lipoprotein lipase (LPL) (insulin (insulin stimulates the synthesis of lipoprotein lipase) stimulates – Low lipoprotein lipase results in the accumulation of VLDLs and Low CMs which mo...
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This note was uploaded on 05/21/2013 for the course DENTAL MED 1501 taught by Professor Misc during the Fall '08 term at Midwestern State University.

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