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Unformatted text preview: n 25 to 40% of newly diagnosed type 1 diabetics
High epinephrine and very low insulin leads to an accelerated rate of
lipolysis. (Epinephrine is high due to the “metabolic stress” caused by
the lack of insulin)
The carnitine shuttle is extremely active because of no insulin.
This leads to an acceleration of β-oxidation and ketogenesis (ketosis) • Diabetic ketoacidosis (DKA) occurs when a patient with ketosis
develops dehydration secondary to polyuria.
dehydration – Dehydration prevents the kidney from excreting the hydrogen ions formed
by ketone bodies (ketone bodies are acids), thus leading to acidosis
by Module #1
Exam #2 Diabetes, Lecture #21 11 Dehydration *Glucagon levels are only elevated in the “uncontrolled
diabetic” early on in the disease process
Exam #2 Diabetes, Lecture #21 12 Metabolic Changes in Type 1 DM
• Hypertriglyceridemia in uncontrolled type 1 DM is due to:
• Increased synthesis of triacylglycerol (the
(the • accelerated lipolysis seen in uncontrolled type 1 DM
results in a huge excess of free fatty acids which the
liver reesterifies to glycerol phosphate to form
Decreased level of lipoprotein lipase (LPL) (insulin
stimulates the synthesis of lipoprotein lipase)
– Low lipoprotein lipase results in the accumulation of VLDLs and
CMs which mo...
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This note was uploaded on 05/21/2013 for the course DENTAL MED 1501 taught by Professor Misc during the Fall '08 term at Midwestern State University.
- Fall '08