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Hypotheses include diet viral infection etc system

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Unformatted text preview: ” It is not known what environmental factors trigger the immune It system. Hypotheses include diet, viral infection, etc. system. The β-cells of the pancreas are destroyed by an autoimmune The process resulting in an absolute deficiency of insulin. Destruction of the β-cells occurs over a period of years however, the Destruction symptoms appear abruptly after 80 to 90% of the β-cells have been destroyed (Reaches a threshold) 90% of patients have anti-islet-cell antibodies at the time of cell diagnosis diagnosis Module #1 Module Exam #2 Diabetes, Lecture #21 5 Decline in insulin Decline secretory capacity in Type 1 Diabetes Mellitus Type Rate of autoimmune destruction of β cells may be faster or slower than shown. Module #1 Module Exam #2 Diabetes, Lecture #21 6 Genetic component more important in Genetic Type 2 than Type 1 Diabetes Mellitus Type • Identical twin studies – If one sibling of a monozygotic twin develops type 1 DM there is a 30 to 50% chance that the second sibling will also develop the disease. disease. – If one sibling of a monozygotic twin deve...
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