Hypotheses include diet viral infection etc system

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ” It is not known what environmental factors trigger the immune It system. Hypotheses include diet, viral infection, etc. system. The β-cells of the pancreas are destroyed by an autoimmune The process resulting in an absolute deficiency of insulin. Destruction of the β-cells occurs over a period of years however, the Destruction symptoms appear abruptly after 80 to 90% of the β-cells have been destroyed (Reaches a threshold) 90% of patients have anti-islet-cell antibodies at the time of cell diagnosis diagnosis Module #1 Module Exam #2 Diabetes, Lecture #21 5 Decline in insulin Decline secretory capacity in Type 1 Diabetes Mellitus Type Rate of autoimmune destruction of β cells may be faster or slower than shown. Module #1 Module Exam #2 Diabetes, Lecture #21 6 Genetic component more important in Genetic Type 2 than Type 1 Diabetes Mellitus Type • Identical twin studies – If one sibling of a monozygotic twin develops type 1 DM there is a 30 to 50% chance that the second sibling will also develop the disease. disease. – If one sibling of a monozygotic twin deve...
View Full Document

This note was uploaded on 05/21/2013 for the course DENTAL MED 1501 taught by Professor Misc during the Fall '08 term at Midwestern State University.

Ask a homework question - tutors are online