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It is not known what environmental factors trigger the immune
system. Hypotheses include diet, viral infection, etc.
The β-cells of the pancreas are destroyed by an autoimmune
process resulting in an absolute deficiency of insulin.
Destruction of the β-cells occurs over a period of years however, the
symptoms appear abruptly after 80 to 90% of the β-cells have been
destroyed (Reaches a threshold)
90% of patients have anti-islet-cell antibodies at the time of
diagnosis Module #1
Exam #2 Diabetes, Lecture #21 5 Decline in insulin
secretory capacity in
Type 1 Diabetes Mellitus
Rate of autoimmune
destruction of β cells
may be faster or
slower than shown. Module #1
Exam #2 Diabetes, Lecture #21 6 Genetic component more important in
Type 2 than Type 1 Diabetes Mellitus
• Identical twin studies – If one sibling of a monozygotic twin develops type 1 DM there is
a 30 to 50% chance that the second sibling will also develop the
– If one sibling of a monozygotic twin deve...
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This note was uploaded on 05/21/2013 for the course DENTAL MED 1501 taught by Professor Misc during the Fall '08 term at Midwestern State University.
- Fall '08