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Unformatted text preview: g normal
blood glucose levels (see panel B)
blood Module #1
Exam #2 Diabetes, Lecture #21 16 Why does Obesity and Insulin
Resistance go Hand-in-Hand?
• Obesity is closely associated with a
• • Module #1
Exam #2 state of low-grade inflammation
Activated macrophages are seen
surrounding dead and dying
adipocytes in the omentum
Activated macrophages release
cytokines (e.g. tumor necrosis
factor, TNF, and IL-6) which appear
to be partially responsible for insulin
resistance associated with obesity
The thiazolidinediones (TZD) are
used to treat type 2 DM and induce
apoptosis in adipocyte
macrophages, thus reducing
adipocyte inflammation and insulin
Diabetes, Lecture #21 17 Blood insulin and
glucose levels in
normal weight and
obese subjects. Module #1
Exam #2 Diabetes, Lecture #21 18 Type 2 Diabetes Mellitus Insulin Resistance is Coupled with Impaired
• Type 2 diabetes will only develop in those individuals who
• also have an impaired β-cell function
Type 2 diabetes is most often seen in people who a...
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This note was uploaded on 05/21/2013 for the course DENTAL MED 1501 taught by Professor Misc during the Fall '08 term at Midwestern State University.
- Fall '08