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Resistance obesity is closely associated with a

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Unformatted text preview: g normal results nondiabetic blood glucose levels (see panel B) blood Module #1 Module Exam #2 Diabetes, Lecture #21 16 Why does Obesity and Insulin Why Resistance go Hand-in-Hand? Resistance • Obesity is closely associated with a Obesity • • • Module #1 Module Exam #2 state of low-grade inflammation state Activated macrophages are seen Activated surrounding dead and dying adipocytes in the omentum adipocytes Activated macrophages release Activated cytokines (e.g. tumor necrosis factor, TNF, and IL-6) which appear factor, 6) to be partially responsible for insulin resistance associated with obesity resistance The thiazolidinediones (TZD) are The used to treat type 2 DM and induce apoptosis in adipocyte macrophages, thus reducing adipocyte inflammation and insulin resistance resistance Diabetes, Lecture #21 17 Blood insulin and glucose levels in normal weight and obese subjects. Module #1 Module Exam #2 Diabetes, Lecture #21 18 Type 2 Diabetes Mellitus Insulin Resistance is Coupled with Impaired Insulin β-Cell Function • Type 2 diabetes will only develop in those individuals who Type • • • also have an impaired β-cell function Type 2 diabetes is most often seen in people who a...
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