Resistance obesity is closely associated with a

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: g normal results nondiabetic blood glucose levels (see panel B) blood Module #1 Module Exam #2 Diabetes, Lecture #21 16 Why does Obesity and Insulin Why Resistance go Hand-in-Hand? Resistance • Obesity is closely associated with a Obesity • • • Module #1 Module Exam #2 state of low-grade inflammation state Activated macrophages are seen Activated surrounding dead and dying adipocytes in the omentum adipocytes Activated macrophages release Activated cytokines (e.g. tumor necrosis factor, TNF, and IL-6) which appear factor, 6) to be partially responsible for insulin resistance associated with obesity resistance The thiazolidinediones (TZD) are The used to treat type 2 DM and induce apoptosis in adipocyte macrophages, thus reducing adipocyte inflammation and insulin resistance resistance Diabetes, Lecture #21 17 Blood insulin and glucose levels in normal weight and obese subjects. Module #1 Module Exam #2 Diabetes, Lecture #21 18 Type 2 Diabetes Mellitus Insulin Resistance is Coupled with Impaired Insulin β-Cell Function • Type 2 diabetes will only develop in those individuals who Type • • • also have an impaired β-cell function Type 2 diabetes is most often seen in people who a...
View Full Document

This note was uploaded on 05/21/2013 for the course DENTAL MED 1501 taught by Professor Misc during the Fall '08 term at Midwestern State University.

Ask a homework question - tutors are online