The nonenzymatic covalent attachment of glucose to

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Unformatted text preview: ule #1 Module Exam #2 Diabetes, Lecture #21 24 Complications •Most of the chronic complications of DM are due to hyperglycemia and are seen in both type 1 & 2 DM •Hyperglycemia results in protein glycation defined as the nonenzymatic, covalent attachment of glucose to protein. Glycation alters the structure and function of proteins and this has serious consequences for the body (May contribute to thickening of blood vessels) Module #1 Module Exam #2 Diabetes, Lecture #21 25 Metabolic Changes in Type 1 & 2 DM etabolic Hemoglobin A1c Hemoglobin s • Hemoglobin A1c iis an example • • of protein glycation of The quantity of HbA1c formed is formed proportional to blood glucose levels levels Hemoglobin A1c (HbA1c) iis s proportional to the average blood glucose level over the previous 6 to 8 weeks and therefore gives an idea of long term glucose levels term – Hb remains in RBC for 120 days Module #1 Module Exam #2 Diabetes, Lecture #21 26 Comparison of Type 1 and Type 2 Diabetes Mellitus Module #1 Module Exam #2 Diabetes, Lecture #21 27...
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This note was uploaded on 05/21/2013 for the course DENTAL MED 1501 taught by Professor Misc during the Fall '08 term at Midwestern State University.

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