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CMs Module #1
Exam #2 Diabetes, Lecture #21 13 Low Lipoprotein lipase
Exam #2 Intertissue relationships
in typeDiabetes, Lecture #21
1 diabetes 14 Type 2 Diabetes Mellitus
• Type 2 DM is also a multifactorial disease. The most
important environmental factors are obesity and
sedentary life style
– Many genes affect weight • Onset of type 2 diabetes is usually preceded by
Onset polyuria and polydipsia but the third ‘P’ of diabetes
(polyphagia) is much less common
– The presence of insulin in type 2 DM prevents hyperphagia • Type 2 diabetes is due to insulin resistance coupled to
dysfunctional β-cells and does not have an autoimmune component Module #1
Exam #2 Diabetes, Lecture #21 15 Type 2 Diabetes Mellitus Insulin Resistance Coupled with Impaired βInsulin
• Insulin resistance involves the inability of target
• • tissues (muscle and adipose) to respond to insulin
Insulin resistance always seen in obesity.
Most obese individuals compensate for insulin resistance by
producing more insulin (lean individuals produce ~30 units
of insulin/day while obese-nondiabetic individuals produce
~115 units/day) (See diagram next slide)
The increased insulin production seen in individuals with IR
results in most obese-nondiabetic individuals havin...
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This note was uploaded on 05/21/2013 for the course DENTAL MED 1501 taught by Professor Misc during the Fall '08 term at Midwestern State University.
- Fall '08