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Typediabetes lecture 21 1 diabetes 14 type 2 diabetes

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Unformatted text preview: stly contain triacylglycerol CMs Module #1 Module Exam #2 Diabetes, Lecture #21 13 Low Lipoprotein lipase Module #1 Module Exam #2 Intertissue relationships in typeDiabetes, Lecture #21 1 diabetes 14 Type 2 Diabetes Mellitus • Type 2 DM is also a multifactorial disease. The most Type important environmental factors are obesity and sedentary life style sedentary – Many genes affect weight • Onset of type 2 diabetes is usually preceded by Onset polyuria and polydipsia but the third ‘P’ of diabetes of (polyphagia) is much less common (polyphagia) – The presence of insulin in type 2 DM prevents hyperphagia • Type 2 diabetes is due to insulin resistance coupled to Type dysfunctional β-cells and does not have an autoimmune component Module #1 Module Exam #2 Diabetes, Lecture #21 15 Type 2 Diabetes Mellitus Insulin Resistance Coupled with Impaired βInsulin Cell Function • Insulin resistance involves the inability of target Insulin • • • tissues (muscle and adipose) to respond to insulin tissues Insulin resistance always seen in obesity. Insulin Most obese individuals compensate for insulin resistance by Most producing more insulin (lean individuals produce ~30 units of insulin/day while obese-nondiabetic individuals produce of nondiabetic ~115 units/day) (See diagram next slide) ~115 The increased insulin production seen in individuals with IR The results in most obese-nondiabetic individuals havin...
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