Lecture 5 - More NS

Lecture 5 - More NS - Hardy-Weinberg Equilibrum Frequency...

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Hardy-Weinberg Equilibrum Frequency of genotypes is p 2 + 2pq + q 2 = 1.0 AA Aa aa Where p = freq. of A allele q = freq. of a allele
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Uses of the Hardy-Weinberg Equation Assume equilibrium to calculate frequencies of genotypes OR If you know the frequencies of genotypes, test whether or not the population is in equilibrium
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Do frequencies in the MN blood group conform to the HW model? MN blood group - co-dominant alleles Frequencies of each genotype are KNOWN
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MN blood group in ESKIMOS Observed: 0.835 MM Observed: 0.156 MN Observed: 0.009 NN M alleles (p) = 0.835 + 1/2(0.156) = 0.913 N alleles (q) = 0.009 + 1/2(0.156) = 0.087 Table 22.1
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Blood types M allele 0.913 = p N allele 0.087 = q Calculate expected using p 2 , 2pq, q 2 p 2 = MM 0.834 2pq = MN 0.159 q 2 = NN 0.008
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Let’s compare Eskimos Observed Expected MM 0.835 0.834 MN 0.156 0.159 NN 0.009 0.008
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MN locus is in H-W equilibrium Large population size No migration No mutations Random mating No natural selection
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Lecture 5 - More NS - Hardy-Weinberg Equilibrum Frequency...

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