mcb450-8s07 - Lecture 8 Nucleotides and Nucleic Acids Do...

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Lecture 8 Nucleotides and Nucleic Acids Do Problem Set #1 on website. Mintel Office Hours – Noyes 208 Thursday 2/8 1:00-2:30 PM Friday 2/9, 10:00-11:30 AM
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Central Dogma of Molecular Biology DNA resides in the nucleus, replicates, and is transcribed into RNA. RNA exits the nucleus and encodes the synthesis of protein in the cytoplasm in the process of translation.
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Central Dogma of Molecular Biology
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Purine and Pyrimidine Rings
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Pyrimidine Bases
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Purine Bases
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Tautomerization Tautomerization is important in explaining how Watson-Crick base pairs form by H bonding.
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Absorption of Ultraviolet Light
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Nucleosides A nucleoside = Base + sugar
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Nucleosides
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Nucleotides A nucleotide = a nucleoside + one or more phosphates
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Nucleotides
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Polynucleotide Chain Nucleotides are held together by 3′-5′ phosphodiester linkages. 3′ 5′
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Polynucleotide Chain Representation A vertical line represents the ribose or deoxyribose, with carbon 1 at the top and carbon 5 at the bottom. C1 C5 P A 3′-5′ phosphodiester bond
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Antiparallel Chains of DNA In the DNA double helix, as one goes from top to bottom, one chain runs in the 5′ to 3′ direction, and the other in the 3′ to 5′ direction.
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This note was uploaded on 04/07/2008 for the course MCB 450 taught by Professor Mintel during the Fall '07 term at University of Illinois at Urbana–Champaign.

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mcb450-8s07 - Lecture 8 Nucleotides and Nucleic Acids Do...

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